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The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2–Sgs1 nuclease-helicase at DNA double strand breaks
Double strand breaks (DSBs) represent highly deleterious DNA damage and need to be accurately repaired. Homology-directed repair and non-homologous end joining (NHEJ) are the two major DSB repair pathways that are highly conserved from yeast to mammals. The choice between these pathways is largely b...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5582849/ https://ncbi.nlm.nih.gov/pubmed/28679532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.796011 |
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