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The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining
Nej1 is an essential factor in the non-homologous end-joining (NHEJ) pathway and interacts with the DNA ligase complex, Lif1-Dnl4, through interactions with Lif1. We have mapped K331-V338 in the C-terminal region of Nej1 to be critical for its functionality during repair. Truncation and alanine scan...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4122420/ https://ncbi.nlm.nih.gov/pubmed/24369855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.12.002 |
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