Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Here we show that epigenetic events govern hepcidin expression. Erythropoiesis and iron defici...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Pasricha, Sant-Rayn, Lim, Pei Jin, Duarte, Tiago L., Casu, Carla, Oosterhuis, Dorenda, Mleczko-Sanecka, Katarzyna, Suciu, Maria, Da Silva, Ana Rita, Al-Hourani, Kinda, Arezes, João, McHugh, Kirsty, Gooding, Sarah, Frost, Joe N., Wray, Katherine, Santos, Ana, Porto, Graça, Repapi, Emmanouela, Gray, Nicki, Draper, Simon J., Ashley, Neil, Soilleux, Elizabeth, Olinga, Peter, Muckenthaler, Martina U., Hughes, Jim R., Rivella, Stefano, Milne, Thomas A., Armitage, Andrew E., Drakesmith, Hal
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581335/
https://ncbi.nlm.nih.gov/pubmed/28864822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00500-z
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