Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Here we show that epigenetic events govern hepcidin expression. Erythropoiesis and iron defici...

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Publié dans:Nat Commun
Auteurs principaux: Pasricha, Sant-Rayn, Lim, Pei Jin, Duarte, Tiago L., Casu, Carla, Oosterhuis, Dorenda, Mleczko-Sanecka, Katarzyna, Suciu, Maria, Da Silva, Ana Rita, Al-Hourani, Kinda, Arezes, João, McHugh, Kirsty, Gooding, Sarah, Frost, Joe N., Wray, Katherine, Santos, Ana, Porto, Graça, Repapi, Emmanouela, Gray, Nicki, Draper, Simon J., Ashley, Neil, Soilleux, Elizabeth, Olinga, Peter, Muckenthaler, Martina U., Hughes, Jim R., Rivella, Stefano, Milne, Thomas A., Armitage, Andrew E., Drakesmith, Hal
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581335/
https://ncbi.nlm.nih.gov/pubmed/28864822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00500-z
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