Erythroferrone inhibits the induction of hepcidin by BMP6

Decreased hepcidin mobilizes iron, which facilitates erythropoiesis, but excess iron is pathogenic in β-thalassemia. Erythropoietin (EPO) enhances erythroferrone (ERFE) synthesis by erythroblasts, and ERFE suppresses hepatic hepcidin production through an unknown mechanism. The BMP/SMAD pathway in t...

Full description

Saved in:
Bibliographic Details
Published in:Blood
Main Authors: Arezes, João, Foy, Niall, McHugh, Kirsty, Sawant, Anagha, Quinkert, Doris, Terraube, Virginie, Brinth, Alette, Tam, May, LaVallie, Edward R., Taylor, Stephen, Armitage, Andrew E., Pasricha, Sant-Rayn, Cunningham, Orla, Lambert, Matthew, Draper, Simon J., Jasuja, Reema, Drakesmith, Hal
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2018
Subjects:
Plenary Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238155/
https://ncbi.nlm.nih.gov/pubmed/30097509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-06-857995
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items