In situ peroxidase labeling and mass-spectrometry connects alpha-synuclein directly to endocytic trafficking and mRNA metabolism in neurons

Synucleinopathies, including Parkinson’s disease (PD), are associated with the misfolding and mistrafficking of alpha-synuclein (α-syn). Here, using an ascorbate peroxidase (APEX)-based labeling method combined with mass spectrometry, we defined a network of proteins in the immediate vicinity of α-s...

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Detaylı Bibliyografya
Yayımlandı:Cell Syst
Asıl Yazarlar: Chung, Chee Yeun, Khurana, Vikram, Yi, Song, Sahni, Nidhi, Loh, Ken H., Auluck, Pavan K., Baru, Valeriya, Udeshi, Namrata D., Freyzon, Yelena, Carr, Steven A., Hill, David E., Vidal, Marc, Ting, Alice Y., Lindquist, Susan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578869/
https://ncbi.nlm.nih.gov/pubmed/28131823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.01.002
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