In situ peroxidase labeling and mass-spectrometry connects alpha-synuclein directly to endocytic trafficking and mRNA metabolism in neurons

Synucleinopathies, including Parkinson’s disease (PD), are associated with the misfolding and mistrafficking of alpha-synuclein (α-syn). Here, using an ascorbate peroxidase (APEX)-based labeling method combined with mass spectrometry, we defined a network of proteins in the immediate vicinity of α-s...

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Publicado en:Cell Syst
Autores principales: Chung, Chee Yeun, Khurana, Vikram, Yi, Song, Sahni, Nidhi, Loh, Ken H., Auluck, Pavan K., Baru, Valeriya, Udeshi, Namrata D., Freyzon, Yelena, Carr, Steven A., Hill, David E., Vidal, Marc, Ting, Alice Y., Lindquist, Susan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578869/
https://ncbi.nlm.nih.gov/pubmed/28131823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.01.002
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