Mechanism of DNA alkylation-induced transcriptional stalling, lesion bypass, and mutagenesis

Alkylated DNA lesions, induced by both exogenous chemical agents and endogenous metabolites, interfere with the efficiency and accuracy of DNA replication and transcription. However, the molecular mechanisms of DNA alkylation-induced transcriptional stalling and mutagenesis remain unknown. In this s...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xu, Liang, Wang, Wei, Wu, Jiabin, Shin, Ji Hyun, Wang, Pengcheng, Unarta, Ilona Christy, Chong, Jenny, Wang, Yinsheng, Wang, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576830/
https://ncbi.nlm.nih.gov/pubmed/28784758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708748114
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