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Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II
Abasic sites are among the most abundant DNA lesions and interfere with DNA replication and transcription, but the mechanism of their action on transcription remains unknown. Here we applied a combined structural and biochemical approach for a comprehensive investigation of how RNA polymerase II (Po...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5856558/ https://ncbi.nlm.nih.gov/pubmed/29487211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722050115 |
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