Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions

In human cells, the oxidative DNA lesion 8,5′-cyclo-2'-deoxyadenosine (CydA) induces prolonged stalling of RNA polymerase II (Pol II) followed by transcriptional bypass, generating both error-free and mutant transcripts with AMP misincorporated immediately downstream from the lesion. Here, we p...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Walmacq, Celine, Wang, Lanfeng, Chong, Jenny, Scibelli, Kathleen, Lubkowska, Lucyna, Gnatt, Averell, Brooks, Philip J., Wang, Dong, Kashlev, Mikhail
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321233/
https://ncbi.nlm.nih.gov/pubmed/25605892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415186112
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