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Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II
RNA polymerase II (Pol II) must overcome the barriers imposed by nucleosomes during transcription elongation. We have developed an optical tweezers assay to follow individual Pol II complexes as they transcribe nucleosomal DNA. Our results indicate that the nucleosome behaves as a fluctuating barrie...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775800/ https://ncbi.nlm.nih.gov/pubmed/19644123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172926 |
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