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Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II

RNA polymerase II (Pol II) must overcome the barriers imposed by nucleosomes during transcription elongation. We have developed an optical tweezers assay to follow individual Pol II complexes as they transcribe nucleosomal DNA. Our results indicate that the nucleosome behaves as a fluctuating barrie...

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Bibliografiske detaljer
Main Authors: Hodges, Courtney, Bintu, Lacramioara, Lubkowska, Lucyna, Kashlev, Mikhail, Bustamante, Carlos
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775800/
https://ncbi.nlm.nih.gov/pubmed/19644123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1172926
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