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Transcription factors IIS and IIF enhance transcription efficiency by differentially modifying RNA polymerase pausing dynamics

Transcription factors IIS (TFIIS) and IIF (TFIIF) are known to stimulate transcription elongation. Here, we use a single-molecule transcription elongation assay to study the effects of both factors. We find that these transcription factors enhance overall transcription elongation by reducing the lif...

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Detalhes bibliográficos
Main Authors: Ishibashi, Toyotaka, Dangkulwanich, Manchuta, Coello, Yves, Lionberger, Troy A., Lubkowska, Lucyna, Ponticelli, Alfred S., Kashlev, Mikhail, Bustamante, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948276/
https://ncbi.nlm.nih.gov/pubmed/24550488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401611111
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