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Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity
Nonenzymatic RNA polymerization in early life is likely to introduce backbone heterogeneity with a mixture of 2′–5′ and 3′–5′ linkages. On the other hand, modern nucleic acids are dominantly composed of 3′–5′ linkages. RNA polymerase II (pol II) is a key modern enzyme responsible for synthesizing 3′...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136571/ https://ncbi.nlm.nih.gov/pubmed/25074911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406234111 |
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