Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy

BACKGROUND. Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the frequency of expression of potential predictive biomarkers is unknown in glioma. METHODS. In this study, we profiled the frequency of shared biomarker phenotypes. To clarify the relationships among tumor...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Principais autores: Hodges, Tiffany R., Ott, Martina, Xiu, Joanne, Gatalica, Zoran, Swensen, Jeff, Zhou, Shouhao, Huse, Jason T., de Groot, John, Li, Shulin, Overwijk, Willem W., Spetzler, David, Heimberger, Amy B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570198/
https://ncbi.nlm.nih.gov/pubmed/28371827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox026
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