Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy

BACKGROUND. Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the frequency of expression of potential predictive biomarkers is unknown in glioma. METHODS. In this study, we profiled the frequency of shared biomarker phenotypes. To clarify the relationships among tumor...

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Vydáno v:Neuro Oncol
Hlavní autoři: Hodges, Tiffany R., Ott, Martina, Xiu, Joanne, Gatalica, Zoran, Swensen, Jeff, Zhou, Shouhao, Huse, Jason T., de Groot, John, Li, Shulin, Overwijk, Willem W., Spetzler, David, Heimberger, Amy B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570198/
https://ncbi.nlm.nih.gov/pubmed/28371827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox026
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