Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas

Gene fusions involving oncogenes have been reported in gliomas and may serve as novel therapeutic targets. Using RNA-sequencing, we interrogated a large cohort of gliomas to assess for the incidence of targetable genetic fusions. Gliomas (n = 390) were profiled using the ArcherDx FusionPlex Assay. F...

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Vydáno v:J Neuropathol Exp Neurol
Hlavní autoři: Ferguson, Sherise D, Zhou, Shouhao, Huse, Jason T, de Groot, John F, Xiu, Joanne, Subramaniam, Deepa S, Mehta, Shwetal, Gatalica, Zoran, Swensen, Jeffrey, Sanai, Nader, Spetzler, David, Heimberger, Amy B
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961205/
https://ncbi.nlm.nih.gov/pubmed/29718398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nly022
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