Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model

Suppressor of Fused (SUFU) is an essential negative regulator of the Hedgehog (HH) pathway and involved in GLI transcription factor regulation. Due to early embryonic lethality of Sufu(−/−) mice, investigations of SUFU’s role later in development are limited to conditional, tissue-specific knockout...

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Publicat a:Dev Biol
Autors principals: Hoelzl, Maria A., Heby-Henricson, Karin, Gerling, Marco, Dias, José M., Kuiper, Raoul V., Trünkle, Cornelius, Bergström, Åsa, Ericson, Johan, Toftgård, Rune, Teglund, Stephan
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569906/
https://ncbi.nlm.nih.gov/pubmed/28688895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2017.06.037
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