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Loss of Trp53 Promotes Medulloblastoma Development but not Skin Tumorigenesis in Sufu Heterozygous Mutant Mice
Basal cell carcinoma of the skin typically carries genetic alterations in components of the hedgehog (HH) signaling pathway. Previously, we generated a knockout mouse with a loss-of-function mutation in suppressor of fused (Sufu), an essential repressor of the pathway downstream of Hh ligand cell su...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3235237/ https://ncbi.nlm.nih.gov/pubmed/21882258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20852 |
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