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Tumor suppressor gene co-operativity in compound Patched1 and Suppressor of fused heterozygous mutant mice

Dysregulation of the Hedgehog signaling pathway is central to the development of certain tumor types, including medulloblastoma and basal cell carcinoma (BCC). Patched1 (Ptch1) and Suppressor of fused (Sufu) are two essential negative regulators of the pathway with tumor suppressor activity. Ptch1(+...

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Библиографические подробности
Главные авторы: Svärd, Jessica, Rozell, Björn, Toftgård, Rune, Teglund, Stephan
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674531/
https://ncbi.nlm.nih.gov/pubmed/18781608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20479
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