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Tumor suppressor gene co-operativity in compound Patched1 and Suppressor of fused heterozygous mutant mice

Dysregulation of the Hedgehog signaling pathway is central to the development of certain tumor types, including medulloblastoma and basal cell carcinoma (BCC). Patched1 (Ptch1) and Suppressor of fused (Sufu) are two essential negative regulators of the pathway with tumor suppressor activity. Ptch1(+...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Svärd, Jessica, Rozell, Björn, Toftgård, Rune, Teglund, Stephan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674531/
https://ncbi.nlm.nih.gov/pubmed/18781608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20479
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