Llwytho...

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

The developmentally important Hedgehog (Hh) signaling pathway has recently been implicated in several forms of solid cancer. Current drug development programs focus on targeting the protooncogene Smoothened, a key transmembrane pathway member. These drug candidates, albeit promising, do not address...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lauth, Matthias, Bergström, Åsa, Shimokawa, Takashi, Toftgård, Rune
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866313/
https://ncbi.nlm.nih.gov/pubmed/17494766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609699104
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