A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors

The vast majority of brain tumors in adults exhibit glial characteristics. Brain tumors in children are diverse: Many have neuronal characteristics, whereas others have glial features. Here we show that activation of the G(i) protein-coupled receptor CXCR4 is critical for the growth of both malignan...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rubin, Joshua B., Kung, Andrew L., Klein, Robyn S., Chan, Jennifer A., Sun, YanPing, Schmidt, Karl, Kieran, Mark W., Luster, Andrew D., Segal, Rosalind A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263845/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14595012/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2235846100
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