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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
The developmentally important Hedgehog (Hh) signaling pathway has recently been implicated in several forms of solid cancer. Current drug development programs focus on targeting the protooncogene Smoothened, a key transmembrane pathway member. These drug candidates, albeit promising, do not address...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1866313/ https://ncbi.nlm.nih.gov/pubmed/17494766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609699104 |
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