EGFR and PDGFRA co-expression and heterodimerization in glioblastoma tumor sphere lines

Concurrent amplifications of EGFR and PDGFRA have been reported in up to 5% of glioblastoma (GBM) and it remains unclear why such independent amplification events, and associated receptor overexpression, would be adaptive during glioma evolution. Here, we document that EGFR and PDGFRA protein co-exp...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Chakravarty, Debyani, Pedraza, Alicia M., Cotari, Jesse, Liu, Angela H., Punko, Diana, Kokroo, Aushim, Huse, Jason T., Altan-Bonnet, Gregoire, Brennan, Cameron W.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567352/
https://ncbi.nlm.nih.gov/pubmed/28831081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08940-9
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