Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

Glioblastoma (GBM) is distinguished by a high degree of intratumoral heterogeneity, which extends to the pattern of expression and amplification of receptor tyrosine kinases (RTKs). Although most GBMs harbor RTK amplifications, clinical trials of small-molecule inhibitors targeting individual RTKs h...

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Main Authors: Szerlip, Nicholas J., Pedraza, Alicia, Chakravarty, Debyani, Azim, Mohammad, McGuire, Jeremy, Fang, Yuqiang, Ozawa, Tatsuya, Holland, Eric C., Huse, Jason T., Jhanwar, Suresh, Leversha, Margaret A., Mikkelsen, Tom, Brennan, Cameron W.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286976/
https://ncbi.nlm.nih.gov/pubmed/22323597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114033109
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