Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

Glioblastoma (GBM) is distinguished by a high degree of intratumoral heterogeneity, which extends to the pattern of expression and amplification of receptor tyrosine kinases (RTKs). Although most GBMs harbor RTK amplifications, clinical trials of small-molecule inhibitors targeting individual RTKs h...

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Autori principali: Szerlip, Nicholas J., Pedraza, Alicia, Chakravarty, Debyani, Azim, Mohammad, McGuire, Jeremy, Fang, Yuqiang, Ozawa, Tatsuya, Holland, Eric C., Huse, Jason T., Jhanwar, Suresh, Leversha, Margaret A., Mikkelsen, Tom, Brennan, Cameron W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286976/
https://ncbi.nlm.nih.gov/pubmed/22323597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114033109
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