Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

Glioblastoma (GBM) is distinguished by a high degree of intratumoral heterogeneity, which extends to the pattern of expression and amplification of receptor tyrosine kinases (RTKs). Although most GBMs harbor RTK amplifications, clinical trials of small-molecule inhibitors targeting individual RTKs h...

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Hlavní autoři: Szerlip, Nicholas J., Pedraza, Alicia, Chakravarty, Debyani, Azim, Mohammad, McGuire, Jeremy, Fang, Yuqiang, Ozawa, Tatsuya, Holland, Eric C., Huse, Jason T., Jhanwar, Suresh, Leversha, Margaret A., Mikkelsen, Tom, Brennan, Cameron W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286976/
https://ncbi.nlm.nih.gov/pubmed/22323597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114033109
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