Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication of eukaryotic chromosomes and protect their ends from recombination, we have measured telomere length, telomerase activity and chromosome rearrangements in human cells be...

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Détails bibliographiques
Auteurs principaux: Counter, C M, Avilion, A A, LeFeuvre, C E, Stewart, N G, Greider, C W, Harley, C B, Bacchetti, S
Format: Artigo
Langue:Inglês
Publié: 1992
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC556651/
https://ncbi.nlm.nih.gov/pubmed/1582420
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