Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication of eukaryotic chromosomes and protect their ends from recombination, we have measured telomere length, telomerase activity and chromosome rearrangements in human cells be...

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Autors principals: Counter, C M, Avilion, A A, LeFeuvre, C E, Stewart, N G, Greider, C W, Harley, C B, Bacchetti, S
Format: Artigo
Idioma:Inglês
Publicat: 1992
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC556651/
https://ncbi.nlm.nih.gov/pubmed/1582420
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