Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

The immortalization of human cells is a critical step during tumorigenesis. In vitro, normal human somatic cells must overcome two proliferative blockades, senescence and crisis, to become immortal. Transformation with viral oncogenes extends the life span of human cells beyond senescence. Such tran...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Counter, Christopher M., Hahn, William C., Wei, Wenyi, Caddle, Stephanie Dickinson, Beijersbergen, Roderick L., Lansdorp, Peter M., Sedivy, John M., Weinberg, Robert A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24516/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843956/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14723
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