Telomere elongation in immortal human cells without detectable telomerase activity.

Immortalization of human cells is often associated with reactivation of telomerase, a ribonucleoprotein enzyme that adds TTAGGG repeats onto telomeres and compensates for their shortening. We examined whether telomerase activation is necessary for immortalization. All normal human fibroblasts tested...

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Bibliographic Details
Main Authors: Bryan, T M, Englezou, A, Gupta, J, Bacchetti, S, Reddel, R R
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC394507/
https://ncbi.nlm.nih.gov/pubmed/7556065
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