2′-Deoxyadenosine 5′-diphosphoribose is an endogenous TRPM2 superagonist

Transient receptor potential melastatin 2 (TRPM2), is a ligand-gated Ca(2+)-permeable non-selective cation channel. While physiological stimuli, e.g. chemotactic agents, evoke controlled Ca(2+) signals via TRPM2, pathophysiological signals, such as reactive oxygen species or genotoxic stress result...

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Foilsithe in:Nat Chem Biol
Main Authors: Fliegert, Ralf, Bauche, Andreas, Wolf Pérez, Adriana-Michelle, Watt, Joanna M., Rozewitz, Monika D., Winzer, Riekje, Janus, Mareike, Gu, Feng, Rosche, Annette, Harneit, Angelika, Flato, Marianne, Moreau, Christelle, Kirchberger, Tanja, Wolters, Valerie, Potter, Barry V.L., Guse, Andreas H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563452/
https://ncbi.nlm.nih.gov/pubmed/28671679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2415
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