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Structural origins of efficient proton abstraction from carbon by a catalytic antibody

Antibody 34E4 catalyzes the conversion of benzisoxazoles to salicylonitriles with high rates and multiple turnovers. The crystal structure of its complex with the benzimidazolium hapten at 2.5-Å resolution shows that a combination of hydrogen bonding, π stacking, and van der Waals interactions is ex...

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Hlavní autoři: Debler, Erik W., Ito, Shuichiro, Seebeck, Florian P., Heine, Andreas, Hilvert, Donald, Wilson, Ian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC555987/
https://ncbi.nlm.nih.gov/pubmed/15788533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409207102
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