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Conformational Isomerism Can Limit Antibody Catalysis
Ligand binding to enzymes and antibodies is often accompanied by protein conformational changes. Although such structural adjustments may be conducive to enzyme catalysis, much less is known about their effect on reactions promoted by engineered catalytic antibodies. Crystallographic and pre-steady...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2423248/ https://ncbi.nlm.nih.gov/pubmed/18417480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710256200 |
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