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Conformational Isomerism Can Limit Antibody Catalysis

Ligand binding to enzymes and antibodies is often accompanied by protein conformational changes. Although such structural adjustments may be conducive to enzyme catalysis, much less is known about their effect on reactions promoted by engineered catalytic antibodies. Crystallographic and pre-steady...

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Detalles Bibliográficos
Main Authors: Debler, Erik W., Müller, Roger, Hilvert, Donald, Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423248/
https://ncbi.nlm.nih.gov/pubmed/18417480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710256200
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