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An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket
Design of catalysts featuring multiple functional groups is a desirable, yet formidable goal. Antibody 13G5, which accelerates the cleavage of unactivated benzisoxazoles, is one of few artificial enzymes that harness an acid and a base to achieve efficient proton transfer. X-ray structures of the Fa...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774029/ https://ncbi.nlm.nih.gov/pubmed/19846764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902700106 |
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