Nalaganje...
An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket
Design of catalysts featuring multiple functional groups is a desirable, yet formidable goal. Antibody 13G5, which accelerates the cleavage of unactivated benzisoxazoles, is one of few artificial enzymes that harness an acid and a base to achieve efficient proton transfer. X-ray structures of the Fa...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774029/ https://ncbi.nlm.nih.gov/pubmed/19846764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902700106 |
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