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Differences in a Conformational Equilibrium Distinguish Catalysis by the Endothelial and Neuronal Nitric-oxide Synthase Flavoproteins
Nitric oxide (NO) is a physiological mediator synthesized by NO synthases (NOS). Despite their structural similarity, endothelial NOS (eNOS) has a 6-fold lower NO synthesis activity and 6–16-fold lower cytochrome c reductase activity than neuronal NOS (nNOS), implying significantly different electro...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2443662/ https://ncbi.nlm.nih.gov/pubmed/18487202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802914200 |
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