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Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis

The signaling molecule nitric oxide (NO) is synthesized in animals by structurally related NO synthases (NOSs), which contain NADPH/FAD- and FMN-binding domains. During catalysis, NADPH-derived electrons transfer into FAD and then distribute into the FMN domain for further transfer to internal or ex...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Dai, Yue, Haque, Mohammad Mahfuzul, Stuehr, Dennis J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399122/
https://ncbi.nlm.nih.gov/pubmed/28232486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777219
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