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Control of Electron Transfer and Catalysis in Neuronal Nitric-oxide Synthase (nNOS) by a Hinge Connecting Its FMN and FAD-NADPH Domains

In nitric-oxide synthases (NOSs), two flexible hinges connect the FMN domain to the rest of the enzyme and may guide its interactions with partner domains for electron transfer and catalysis. We investigated the role of the FMN-FAD/NADPH hinge in rat neuronal NOS (nNOS) by constructing mutants that...

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Main Authors: Haque, Mohammad Mahfuzul, Fadlalla, Mohammed A., Aulak, Kulwant S., Ghosh, Arnab, Durra, Deborah, Stuehr, Dennis J.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436266/
https://ncbi.nlm.nih.gov/pubmed/22722929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.339697
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