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Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9

Catalytic antibody 14D9 catalyzes the enantioselective protonation of prochiral enol ethers with high enantioselectivity (>99% ee) and a practical turnover (k(cat) = 0.4 s(-1)), allowing for preparative scale applications. This antibody represents one of the rare examples of catalytic antibodies...

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Autors principals: Zheng, Lei, Baumann, Ulrich, Reymond, Jean-Louis
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC376184/
https://ncbi.nlm.nih.gov/pubmed/14988504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400263101
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