CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients

AIM: Oxycodone is partly metabolized to the active metabolite oxymorphone by hepatic CYP2D6 in the liver. Significant genetic variability in CYP2D6 activity affects oxymorphone formation. This study aimed to associate CYP2D6 genotype and oxycodone's metabolism. METHODS: 30 children were adminis...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Pharmacogenomics
Hlavní autoři: Balyan, Rajiv, Mecoli, Marc, Venkatasubramanian, Raja, Chidambaran, Vidya, Kamos, Nichole, Clay, Smokey, Moore, David L, Mavi, Jagroop, Glover, Chris D, Szmuk, Peter, Vinks, Alexander, Sadhasivam, Senthilkumar
Médium: Artigo
Jazyk:Inglês
Vydáno: Future Medicine Ltd 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558529/
https://ncbi.nlm.nih.gov/pubmed/28244808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2016-0183
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky