CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients

AIM: Oxycodone is partly metabolized to the active metabolite oxymorphone by hepatic CYP2D6 in the liver. Significant genetic variability in CYP2D6 activity affects oxymorphone formation. This study aimed to associate CYP2D6 genotype and oxycodone's metabolism. METHODS: 30 children were adminis...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Pharmacogenomics
Main Authors: Balyan, Rajiv, Mecoli, Marc, Venkatasubramanian, Raja, Chidambaran, Vidya, Kamos, Nichole, Clay, Smokey, Moore, David L, Mavi, Jagroop, Glover, Chris D, Szmuk, Peter, Vinks, Alexander, Sadhasivam, Senthilkumar
Format: Artigo
Jezik:Inglês
Izdano: Future Medicine Ltd 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558529/
https://ncbi.nlm.nih.gov/pubmed/28244808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2016-0183
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