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POPULATION PHARMACOKINETIC-PHARMACODYNAMIC MODELING AND DOSING SIMULATION OF PROPOFOL MAINTENANCE ANESTHESIA IN SEVERELY OBESE ADOLESCENTS

BACKGROUND: Optimal dosing of propofol to maintain appropriate anesthetic depth is challenging in severely obese (SO) adolescents. We previously reported that total body weight (TBW) is predictive of propofol clearance. This study was aimed at characterizing pharmacokinetics (PK) and pharmacodynamic...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Paediatr Anaesth
Main Authors: Chidambaran, Vidya, Venkatasubramanian, Raja, Sadhasivam, Senthilkumar, Esslinger, Hope, Cox, Shareen, Diepstraten, Jeroen, Fukuda, Tsuyoshi, Inge, Thomas, Knibbe, Catherijne A.J., Vinks, Alexander A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516654/
https://ncbi.nlm.nih.gov/pubmed/25975390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pan.12684
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