POPULATION PHARMACOKINETIC-PHARMACODYNAMIC MODELING AND DOSING SIMULATION OF PROPOFOL MAINTENANCE ANESTHESIA IN SEVERELY OBESE ADOLESCENTS

BACKGROUND: Optimal dosing of propofol to maintain appropriate anesthetic depth is challenging in severely obese (SO) adolescents. We previously reported that total body weight (TBW) is predictive of propofol clearance. This study was aimed at characterizing pharmacokinetics (PK) and pharmacodynamic...

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Vydáno v:Paediatr Anaesth
Hlavní autoři: Chidambaran, Vidya, Venkatasubramanian, Raja, Sadhasivam, Senthilkumar, Esslinger, Hope, Cox, Shareen, Diepstraten, Jeroen, Fukuda, Tsuyoshi, Inge, Thomas, Knibbe, Catherijne A.J., Vinks, Alexander A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516654/
https://ncbi.nlm.nih.gov/pubmed/25975390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pan.12684
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