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Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of drugs – method development and application to magnesium in sheep

BACKGROUND: There have been few reports of pharmacokinetic models that have been linked to models of the cardiovascular system. Such models could predict the cardiovascular effects of a drug under a variety of circumstances. Limiting factors may be the lack of a suitably simple cardiovascular model,...

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Detalhes bibliográficos
Main Authors: Upton, Richard N, Ludbrook, Guy L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC555767/
https://ncbi.nlm.nih.gov/pubmed/15760466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-5-5
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