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Pharmacokinetics/pharmacodynamics and the stages of drug development: Role of modeling and simulation

Pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation (M&S) are well-recognized powerful tools that enable effective implementation of the learn-and-confirm paradigm in drug development. The impact of PK/PD M&S on decision making and drug development risk management is depend...

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Detalhes bibliográficos
Main Authors: Chien, Jenny Y., Friedrich, Stuart, Heathman, Michael A., de Alwis, Dinesh P., Sinha, Vikram
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751257/
https://ncbi.nlm.nih.gov/pubmed/16353932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/aapsj070355
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