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Molecular origin of constant m-values, denatured state collapse, and residue-dependent transition midpoints in globular proteins

Experiments show that for many two state folders the free energy of the native state ΔG(ND)([C]) changes linearly as the denaturant concentration [C] is varied. The slope, [Formula: see text] , is nearly constant. According to the Transfer Model, the m-value is associated with the difference in the...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: O’Brien, Edward P., Brooks, Bernard R., Thirumalai, D.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551902/
https://ncbi.nlm.nih.gov/pubmed/19278261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8021119
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