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Engineered Cpf1 variants with altered PAM specificities increase genome targeting range
The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells(1–7). However, the utility of the commonly used Acidaminococcus sp. BV3L6 Cpf1 (AsCpf1) and Lachnospiraceae bacterium ND2006 Cpf1 (LbCpf1) is limited by their requirement of a TTTV protospacer adjacent motif...
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| Publicado no: | Nat Biotechnol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5548640/ https://ncbi.nlm.nih.gov/pubmed/28581492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3900 |
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