Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants

Cpf1s, the RNA-guided nucleases of the class II clustered regularly interspaced short palindromic repeats system require a short motive called protospacer adjacent motif (PAM) to be present next to the targeted sequence for their activity. The TTTV PAM sequence of As- and LbCpf1 nucleases is relativ...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Tóth, Eszter, Czene, Bernadett C, Kulcsár, Péter I, Krausz, Sarah L, Tálas, András, Nyeste, Antal, Varga, Éva, Huszár, Krisztina, Weinhardt, Nóra, Ligeti, Zoltán, Borsy, Adrienn É, Fodor, Elfrieda, Welker, Ervin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212782/
https://ncbi.nlm.nih.gov/pubmed/30239882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky815
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