Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells

BACKGROUND: Cpf1 nucleases have recently been repurposed for site-specific genome modification. Two members of the Cpf1 family, the AsCpf1 from Acidaminococcus sp. and the LbCpf1 from Lachnospiraceae bacterium were shown to induce higher indel frequencies than SpCas9 when examining four randomly-sel...

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Detalhes bibliográficos
Publicado no:Biol Direct
Main Authors: Tóth, Eszter, Weinhardt, Nóra, Bencsura, Petra, Huszár, Krisztina, Kulcsár, Péter I., Tálas, András, Fodor, Elfrieda, Welker, Ervin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024423/
https://ncbi.nlm.nih.gov/pubmed/27630115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13062-016-0147-0
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