Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9

The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets bearing a protospacer adjacent motif (PAM) and complementarity to an RNA guide. Unlike other Cas9 orthologs, Corynebacterium diphtheriae Cas9 (CdCas9) recognizes the promiscuous NNRHHHY PAM. However, the CdCas9-mediated PAM rec...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Hirano, Seiichi, Abudayyeh, Omar O., Gootenberg, Jonathan S., Horii, Takuro, Ishitani, Ryuichiro, Hatada, Izuho, Zhang, Feng, Nishimasu, Hiroshi, Nureki, Osamu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488586/
https://ncbi.nlm.nih.gov/pubmed/31036811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09741-6
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